Clinicopathological correlation of psychosis and brain vascular burden in
Alzheimer's disease
 
   Lead Investigator:    Simon Kang Seng Ting
   Institution      :    Department of Neurology, Singapore General Hospita
   E-Mail           :    simon.ting.k.s@sgh.com.sg
   Proposal ID      :    381


   Publications:


1  Hao Y, Hameed S, Ting S
   Clinicopathological Investigation of Psychosis in Alzheimer's disease using an Advanced Decision Tree Algorithm
   2014   Abstract  SingHealth Duke-NUS Scientific Congress , 

   ACCEPTED



2  Ting SKS, Hao Y, Chia PSP, Tan EK, Hameed S
   Clinicopathological correlation of psychosis and brain vascular changes in Alzheimer's disease
   Journal Article  Sci Rep,6:20858,2017,PMC4751434

   PUBLISHED





   Proposal Description:
   Psychosis is common manifestation of Alzheimer's disease (AD) especially in  the late stage of disease. Pathological studies suggest its presence correlates with neuropathological burden of neurofibrillary tangles and amyloid plaques  that typically found in AD [1,2]. Vascular burden has been implicated with clinical psychosis in non-AD study [3]. To date, evidence of vascular burden   contributing to psychosis in AD remains sparse in literature. There are also no studies looking into relationship of presence of heamorrhages and amyloid angiopathy with psychosis in AD. The aim of our study is to delineate the clinicopathological relationship of psychosis and brain vascular burden in AD. We hypothesize presence of vascular lesions in brain is positively correlated to severity of clinical psychosis in AD.